Project publications

Monica Centa, Kajsa E. Prokopec, Manasa Garimella, Katrin Habir, Lisa Hofste, Julian Stark, Albert Dahdah, Chris Tibbit, Konstantinos A. Polyzos, Anton Gisterå, Daniel K. Johansson, Nobuyo N. Maeda, Göran K. Hansson, Daniel F.J. Ketelhuth, Jonathan Coquet, Christoph J. Binder, Mikael C. I. Karlsson and Stephen Malin Acute loss of Apolipoprotein E triggers an autoimmune response that accelerates atherosclerosis. Arterioscler Thromb Vasc Biol. 2018 in press

Carbone F, Nulli Migliola E, Bonaventura A, Vecchié A, De Vuono S, Ricci MA, Vaudo G, Boni M, Dallegri F, Montecucco F, Lupattelli G. High serum levels of C-reactive protein (CRP) predict beneficial decrease of visceral fat in obese females after sleeve gastrectomy. Nutr Metab Cardiovasc Dis. 2018 Feb 2. pii: S0939-4753(18)30049-8. doi: 10.1016/j.numecd.2018.01.014. [Epub ahead of print]

Oleinika K, Rosser EC, Matei DE, Nistala K, Bosma A, Drozdov I, Mauri C. CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells. Nat Commun. 2018 Feb 15;9(1):684. doi: 10.1038/s41467-018-02911-y.

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Bonaventura A, Gallo F, Carbone F, Liberale L, Maggi D, Sacchi G, Dallegri F, Montecucco F, Cordera R. Levels of serum uric acid at admission for hypoglycaemia predict 1-year mortality. Acta Diabetol. 2018 Apr;55(4):323-330. doi: 10.1007/s00592-017-1094-7. Epub 2018 Jan 11.

Liberale L, Carbone F, Bertolotto M, Bonaventura A, Vecchié A, Mach F, Burger F, Pende A, Spinella G, Pane B, Palombo D, Dallegri F, Montecucco F. Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis. Vascul Pharmacol. 2018 Mar;102:37-43. doi: 10.1016/j.vph.2017.12.066. Epub 2018 Jan 2

Carbone F, Rigamonti F, Burger F, Roth A, Bertolotto M, Spinella G, Pane B, Palombo D, Pende A, Bonaventura A, Liberale L, Vecchié A, Dallegri F, Mach F, Montecucco F. Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis. Int J Cardiol. 2018 Mar 15;255:195-199. doi: 10.1016/j.ijcard.2018.01.008. Epub 2018 Jan 5

Bonaventura A, Liberale L, Carbone F, Vecchié A, Diaz-Cañestro C, Camici GG, Montecucco F, Dallegri F. The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases. Thromb Haemost. 2018 Jan;118(1):6-27. doi: 10.1160/TH17-09-0630. Epub 2018 Jan 5.

Rigamonti F, Carbone F, Montecucco F, Bonaventura A, Liberale L, Burger F, Roth A, Bertolotto M, Spinella G, Pane B, Palombo D, Pende A, Dallegri F, Mach F, Bertolini S, Pisciotta L. Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis. Eur J Clin Invest. 2018 Mar;48(3). doi: 10.1111/eci.12888. Epub 2018 Feb 2.

Meeuwsen JAL, Wesseling M, Hoefer IE, de Jager SCA. Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease. Front Cardiovasc Med. 2017 Jul 14;4:44. doi: 10.3389/fcvm.2017.00044. eCollection 2017. Review.

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Liberale L, Montecucco F, Camici GG, Dallegri F, Vecchie A, Carbone F, Bonaventura A. Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes. Curr Med Chem. 2017;24(14):1403-1416. doi: 10.2174/0929867324666170303123734

Bonaventura A, Gallo F, Carbone F, Sacchi G, Liberale L, Dallegri F, Maggi D, Montecucco F, Cordera R. Low serum C-reactive protein levels predict 90-day mortality in hypoglycaemic patients. Diabetes Metab. 2017 Dec;43(6):554-556. doi: 10.1016/j.diabet.2017.05.008. Epub 2017 Jul 4.

Bonaventura A, Liberale L, Carbone F, Scopinaro N, Camerini G, Papadia FS, Cordera R, Dallegri F, Adami GF, Montecucco F. High baseline C-reactive protein levels predict partial type 2 diabetes mellitus remission after biliopancreatic diversion. Nutr Metab Cardiovasc Dis. 2017 May;27(5):423-429. doi: 10.1016/j.numecd.2017.01.007. Epub 2017 Feb 3.

Liberale L, Montecucco F, Bonaventura A, Casetta I, Seraceni S, Trentini A, Padroni M, Dallegri F, Fainardi E, Carbone F. Monocyte count at onset predicts poststroke outcomes during a 90-day follow-up. Eur J Clin Invest. 2017 Oct;47(10):702-710. doi: 10.1111/eci.12795. Epub 2017 Sep 2

Liberale L, Bonaventura A, Carbone F, Bertolotto M, Contini P, Scopinaro N, Camerini GB, Papadia FS, Cordera R, Camici GG, Dallegri F, Adami GF, Montecucco F. Early reduction of matrix metalloproteinase-8 serum levels is associated with leptin drop and predicts diabetes remission after bariatric surgery. Int J Cardiol. 2017 Oct 15;245:257-262. doi: 10.1016/j.ijcard.2017.07.044. Epub 2017 Jul 13

Meeuwsen JAL, van Duijvenvoorde A, Gohar A, van de Weg SM,. Gijsberts CM, Haitjema S, Björkbacka H. Fredrikson GN,. den Ruijter HM, Pasterkamp G, Hoefer IE, de Jager SCA. High levels of (un)switched memory B cells associate with better outcome in patients with advanced atherosclerotic disease. J Am Heart Assoc. 2017 Sep 7;6(9). pii: e005747. doi: 10.1161/JAHA.117.005747

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Albert Dahdah, Katrin Habir, Kutty Selva Nandakumar, Amit Saxena, Xu Bingze, Rikard Holmdahl, Stephen Malin. Germinal center B cells are essential for collagen-induced arthritis. Arthritis Rheumatol. 2018 Feb;70(2):193-203. doi: 10.1002/art.40354. Epub 2018 Jan 22.

Vecchié A, Dallegri F, Carbone F, Bonaventura A, Liberale L, Portincasa P, Frühbeck G, Montecucco F. Obesity phenotypes and their paradoxical association with cardiovascular diseases. Eur J Intern Med. 2018 Feb;48:6-17. doi: 10.1016/j.ejim.2017.10.020.

Katrin Habir, Shahin Aeinehband, Fredrik Wermeling and Stephen Malin. A role for the transcription factor Arid3a in mouse B2 cell expansion and peritoneal B1a generation. Front Immunol. 2017 Oct 24;8:1387. doi: 10.3389/fimmu.2017.01387. eCollection 2017.

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Casula M, Montecucco F, Bonaventura A, Liberale L, Vecchié A, Dallegri F, Carbone F. Update on the role of Pentraxin 3 in atherosclerosis and cardiovascular diseases. Vascul Pharmacol. 2017 Dec;99:1-12. doi: 10.1016/j.vph.2017.10.003. Epub 2017 Oct 16.

Carbone F, Liberale L, Bonaventura A, Vecchiè A, Casula M, Cea M, Monacelli F, Caffa I, Bruzzone S, Montecucco F, Nencioni A. Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase / Visfatin. Compr Physiol. 2017 Mar 16;7(2):603-621. doi: 10.1002/cphy.c160029.

Montecucco F, Liberale L, Bonaventura A, Vecchiè A, Dallegri F, Carbone F. The Role of Inflammation in Cardiovascular Outcome. Curr Atheroscler Rep. 2017 Mar;19(3):11. doi: 10.1007/s11883-017-0646-1

Liberale L, Dallegri F, Montecucco F, Carbone F. Pathophysiological relevance of macrophage subsets in atherogenesis. Thromb Haemost. 2017 Jan 5;117(1):7-18. doi: 10.1160/TH16-08-0593. Epub 2016 Sep 29. Review

Bonaventura A, Mach F, Roth A, Lenglet S, Burger F, Brandt KJ, Pende A, Bertolotto M, Spinella G, Pane B, Palombo D, Dallegri F, Cea M, Vuilleumier N, Montecucco F, Carbone F. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis. Mediators Inflamm. 2016;2016:9153673. Epub 2016 Sep 21

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Bonaventura A, Liberale L, Vecchié A, Casula M, Carbone F, Dallegri F, Montecucco F. Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke. Int J Mol Sci. 2016 Nov 25;17(12). pii: E1967.

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Carbone F, Crowe LA, Roth A, Burger F, Lenglet S, Braunersreuther V, Brandt KJ, Quercioli A, Mach F, Vallée JP, Montecucco F. Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury. J Mol Cell Cardiol. 2016 May;94:82-94. doi: 10.1016/j.yjmcc.2016.03.013. Epub 2016 Apr 5

Carbone F, Satta N, Montecucco F, Virzi J, Burger F, Roth A, Roversi G, Tamborino C, Casetta I, Seraceni S, Trentini A, Padroni M, Dallegri F, Lalive PH, Mach F, Fainardi E, Vuilleumier N. Anti-ApoA-1 IgG serum levels predict worse poststroke outcomes. Eur J Clin Invest. 2016 Sep;46(9):805-17. doi: 10.1111/eci.12664

Liberale L, Montecucco F, Casetta I, Seraceni S, Trentini A, Padroni M, Dallegri F, Mach F, Fainardi E, Carbone F. Decreased serum PCSK9 levels after ischaemic stroke predict worse outcomes. Eur J Clin Invest. 2016 Dec;46(12):1053-1062. doi: 10.1111/eci.12692. Epub 2016 Nov 10

Carbone F, Satta N, Burger F, Roth A, Lenglet S, Pagano S, Lescuyer P, Bertolotto M, Spinella G, Pane B, Palombo D, Pende A, Dallegri F, Mach F, Vuilleumier N, Montecucco F. Vitamin D receptor is expressed within human carotid plaques and correlates with pro-inflammatory M1 macrophages. Vascul Pharmacol. 2016 Oct;85:57-65. doi: 10.1016/j.vph.2016.08.004. Epub 2016 Aug 20.

Pagano S, Carbone F, Burger F, Roth A, Bertolotto M, Pane B, Spinella G, Palombo D, Pende A, Dallegri F, Satta N, Virzi J, Fontana P, Mach F, Montecucco F, Vuilleumier N. Anti-Apolipoprotein A-1 autoantibodies as active modulators of atherothrombosis. Thromb Haemost. 2016 Aug 30;116(3):554-64. doi: 10.1160/TH16-03-0229. Epub 2016 Jun 30.

Montecucco F, Bondarenko AI, Lenglet S, Burger F, Piscitelli F, Carbone F, Roth A, Liberale L, Dallegri F, Brandt KJ, Fraga-Silva RA, Stergiopulos N, Di Marzo V, Mach F. Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis. Thromb Haemost. 2016 Oct 28;116(5):987-997. Epub 2016 Jul 28.

Carbone F, Satta N, Montecucco F, Virzi J, Burger F, Roth A, Roversi G, Tamborino C, Casetta I, Seraceni S, Trentini A, Padroni M, Dallegri F, Lalive PH, Mach F, Fainardi E, Vuilleumier N. Anti-ApoA-1 IgG serum levels predict worse post-stroke outcomes. Eur J Clin Invest. 2016 Sep;46(9):805-17. doi: 10.1111/eci.12664.

Carbone F, Bonaventura A, Liberale L, Cea M, Montecucco F. Targeting inflammation in primary cardiovascular prevention. Curr Pharm Des. 2016;22(37):5662-5675.

Liberale L, Bonaventura A, Dallegri F, Montecucco F, Carbone F. Impact of red wine consumption on cardiovascular health. Curr Med Chem. 2017 May 17. doi:10.2174/0929867324666170518100606. [Epub ahead of print].

Strom AC, Cross AJ, Cole JE, Blair PA, Leib C, Goddard ME, Rosser EC, Park I, Hultgårdh Nilsson A, Nilsson J, Mauri C, Monaco C. B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10. Thromb Haemost. 2015 Oct;114(4):835-47. doi: 10.1160/TH14-12-1084. Epub 2015 Jun 11.

Cole JE, Astola N, Cribbs AP, Goddard ME, Park I, Green P, Davies AH, Williams RO, Feldmann M, Monaco C. Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13033-8. doi: 10.1073/pnas.1517820112.

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Bornschein J, Nielitz J, Drozdov I, Selgrad M, Wex T, Jechorek D, Link A, Vieth M, Malfertheiner P. Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer. Cancer Med. 2016 Mar;5(3):516-26. doi: 10.1002/cam4.610. Epub 2016 Jan 18.

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Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S. Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1) : 25-36. doi: 10.1161/ATVBAHA.115.305990. Epub 2015 Nov 12.

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Björkbacka H, Alm R, Persson M, Hedblad B, Nilsson J, Fredrikson GN. Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):765-71. doi: 10.1161/ATVBAHA.115.306938. Epub 2016 Feb 25.

Carbone F, Burger F, Roversi G, Tamborino C, Casetta I, Seraceni D, Trentini A, Padroni M, Bertolotto M, Dallegri F, Mach F, Fainardi E, Montecucco F. Leptin/adiponectin ratio predicts post-stroke neurological outcome. Eur J Clin Invest. 2015 Nov;45(11):1184-91. doi: 10.1111/eci.12538. Epub 2015 Oct 19.

Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul Pharmacol. 2015 Sep;72:197-208. doi: 10.1016/j.vph.2015.04.008. Epub 2015 Apr 25.

Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016 Jan;8(1):34-49.

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Carbone F, Crowe LA, Roth A, Burger F, Lenglet S, Braunersreuther V, Brandt KJ, Quercioli A, Mach F, Vallée JP, Montecucco F. Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury. J Mol Cell Cardiol. 2016 May; 94:82-94. doi: 10.1016/j.yjmcc.2016.03.013. Epub 2016 Apr 5.

Pende A, Artom N, Bertolotto M, Montecucco F, Dallegri F. Role of Neutrophils in Atherogenesis: an Update. Eur J Clin Invest. 2016 Mar;46(3):252-63. doi: 10.1111/eci.12566. Epub 2016 Feb 2. Review.

Gomes Quinderé AL, Barros Benevides NM, Pelli G, Lenglet S, Burger F, Carbone F, Fraga-Silva RA, Stergiopulos N, Pagano S, Bertolotto M, Dallegri F, Vuilleumier N, Mach F, Montecucco F. Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice. Vascul Pharmacol. 2015 Aug;71:84-92. doi: 10.1016/j.vph.2015.02.015. Epub 2015 Apr 10.

Montecucco F, Braunersreuther V, Burger F, Lenglet S, Pelli G, Carbone F, Fraga-Silva RA, Stergiopulos N, Monaco C, Mueller C, Pagano S, Dallegri F, Mach F, Vuilleumier N. Anti-apoA-1 auto-antibodies increase mouse atherosclerotic plaque vulnerability, myocardial necrosis and mortality triggering TLR2 and TLR4. Thromb Haemost. 2015 Aug;114(2):410-22. doi: 10.1160/TH14-12-1039. Epub 2015 Apr 16.

Rubini Gimenez M, Pagano S, Virzi J, Montecucco F, Twerenbold R, Reichlin T, Wildi K, Grueter D, Jaeger C, Haaf P, Vuilleumier N, Mueller C. Diagnostic and prognostic value of autoantibodies anti-apolipoprotein A-1 and anti-phosphorylcholine in acute non-ST elevation myocardial infarction. Eur J Clin Invest. 2015 Apr;45(4):369-79. doi: 10.1111/eci.12411. Epub 2015 Mar 9.

Montecucco F, Lenglet S, Quercioli A, Burger F, Thomas A, Lauer E, da Silva AR, Mach F, Vuilleumier N, Bobbioni-Harsch E, Golay A, Schindler TH, Pataky Z. Gastric bypass in morbid obese patients is associated with reduction in adipose tissue inflammation via N-oleoylethanolamide (OEA)-mediated pathways. Thromb Haemost. 2015 Apr;113(4):838-50. doi: 10.1160/TH14-06-0506. Epub 2014 Nov 20.

Akhmedov A, Montecucco F, Braunersreuther V, Camici GG, Jacob P, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée JP, Mach F, Lüscher TF. Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischemic myocardial injury via intracellular salvage pathways. Eur Heart J. 2015 Feb 21;36(8):516-26a. doi: 10.1093/eurheartj/ehu400. Epub 2014 Oct 21.

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Carbone F, Mach F, Montecucco F. The role of adipocytokines in atherogenesis and atheroprogression. Curr Drug Targets. 2015;16(4):295-320. Review.

Carbone F, Mach F, Montecucco F. Update on the role of neutrophils in atherosclerotic plaque vulnerability. Curr Drug Targets. 2015;16(4):321-33. Review.

Carbone F, Teixeira PC, Braunersreuther V, Mach F, Vuilleumier N, Montecucco F. Pathophysiology and treatments of oxidative injury in ischemic stroke: focus on the phagocytic NADPH oxidase (NOX) 2. Antioxid Redox Signal. 2015 Aug 10;23(5):460-89. doi: 10.1089/ars.2013.5778. Epub 2014 Apr 22. Review.

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Carbone F, Bovio M, Rosa GM, Ferrando F, Scarrone A, Murialdo G, Quercioli A, Vuilleumier N, Mach F, Viazzi F, Montecucco F. Inferior vena cava parameters predict readmission in ischemic heart failure. Eur J Clin Invest. 2014;44:341-9. doi: 10.1111/eci.12238. Epub 2014 Feb 8.

Carbone F, Mach F, Vuilleumier N, Montecucco F. Cannabinoid receptor type 2 activation in atherosclerosis and acute cardiovascular diseases. Curr Med Chem. 2014;21:4046-58.

Carbone F, Mach F, Vuilleumier N, Montecucco F. Potential pathophysiological role for the vitamin D deficiency in essential hypertension. World J Cardiol. 2014;6:260-276. doi: 10.4330/wjc.v6.i5.260. Review.

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Rosa GM, Carbone F, Parodi A, Massimelli EA, Brunelli C, Mach F, Vuilleumier N, Montecucco F. Update on the efficacy of statin treatment in Acute Coronary Syndromes. Eur J Clin Invest. 2014;44:501-15. doi: 10.1111/eci.12255. Review.

Sanguineti R, Puddu A, Mach F, Montecucco F, Viviani GL. Advanced Glycation End-Products (AGEs) play adverse pro-inflammatory activities in osteoporosis. Mediators Inflamm. 2014;2014:975872. doi: 10.1155/2014/975872. Epub 2014 Mar 20. Review.

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Quinderé AL, Barros Benevides NM, Carbone F, Mach F, Vuilleumier N, Montecucco F. Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis. Thromb Haemost. 2014;111:634-46. doi: 10.1160/TH13-08-0712. Epub 2013 Nov 28. Review.

Artom N, Montecucco F, Mach F, Dallegri F, Pende A. Angiotensin II Receptor Antagonists in Acute Coronary Syndromes. Eur J Clin Invest. 2014;44:219-230. doi: 10.1111/eci.12198. Epub 2013 Dec 2.

Montecucco F, Mach F, Lenglet S, Vonlaufen A, Gomes Quinderé AL, Pelli G, Burger F, Galan K, Dallegri F, Carbone F, Proudfoot AE, Vuilleumier N, Frossard JL. Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis. Eur J Clin Invest. 2014;44:940-50. doi: 10.1111/eci.12327.

Lenglet S, Montecucco F, Mach F, Schaller K, Gasche Y, Copin JC. Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischemic stroke. Thromb Haemost. 2014;112:363-78. doi: 10.1160/TH14-01-0007. Epub 2014 Mar 27.

Lenglet S, Montecucco F, Denes A, Coutts G, Pinteaux E, Mach F, Schaller K, Gasche Y, Copin JC. Recombinant tissue plasminogen activator enhances microglial cell recruitment after stroke in mice. J Cereb Blood Flow Metab. 2014;34:802-12. doi: 10.1038/jcbfm.2014.9. Epub 2014 Jan 29.